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KMID : 0848120140390020075
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International Journal of Oral Biology
2014 Volume.39 No. 2 p.75 ~ p.79
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Antimicrobial Effects of Oleanolic Acid, Ursolic Acid, and Sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes
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Jo Eo-Jin
Choi Mi-Hwa
Kim Hwa-Sook
Park Soon-Nang
Lim Yun-Kyong
Kang Christina-K
Kook Joong-Ki
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Abstract
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The aim of this study was to investigate antimicrobial effect of oleanolic acid (OA), ursolic acid (UA), and sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes, which are the major causative bacteria of endodontic infections. The antimicrobial activity was evaluated by the minimal inhibitory concentration (MIC). The data showed that the OA, UA, and sophoraflavanone G had antimicrobial effect on all the strains use in the study with 16-64 μg/ml, 8-64 μg/ml, and 1-8 μg/ml of MIC values, respectively. These results indicate that OA, UA, and sophoraflavanone G could be useful in the development of antiseptic solution for washing the root canal in endodontic treatments.
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KEYWORD
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antimicrobial effect , oleanolic acid , ursolic acid , sophoraflavanone G , Enterococcus faecalis , Propionibacterium acnes
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